Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tg(HTT*)NXwy
Name:	transgene insertion N, X William Yang
MGI ID:	MGI:5635152
Synonyms:	BACHD-deltaN17
Transgene:	Tg(HTT*)NXwy  Location: unknown
Alliance:	Tg(HTT*)NXwy page

Strain of Origin:

FVB/NJ

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(HTT*)NXwy expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human HTT (3064) Htt  (MGI:96067) Expresses a BAC with the first 17 amino acids deleted and exon 1 recplaced with 97 CAA-CAG repeats   Mutation details: The 240 kb human bacterial artificial chromosome (BAC RP11-866L6), containing the entire 170 kb human Huntingtin genomic locus and approximately 20 kbp of 5' and 50 kbp of 3' flanking sequences and modified to replace the human HTT exon 1 with a loxP-flanked human mutant HTT exon 1 sequence containing 97 mixed CAA-CAG repeats encoding a continuous polyglutamine stretch was further modified to delete the first 17-amino-acid domain (N17; residues 2-16). This modified BAC containing both the 97Q and the deleted N17 domain was microinjected into FVB/NJ fertilized eggs. Three founders were established; N, L, and A. Line N and L show a similar level of expression. (J:219890)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:219890 Gu X, et al., N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice. Neuron. 2015 Feb 18;85(4):726-41
All:	2 reference(s)