Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Irf8tm2.1Hm
Name:	interferon regulatory factor 8; targeted mutation 2.1, Herbert Morse III
MGI ID:	MGI:5618103
Synonyms:	IRF8-EGFP
Gene:	Irf8  Location: Chr8:121463097-121483433 bp, + strand  Genetic Position: Chr8, 70.05 cM
Alliance:	Irf8tm2.1Hm page

Germline Transmission:	Earliest citation of germline transmission: J:218664
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Reporter) Mutation:    Insertion   Mutation details: The targeting vector is designed to replace the stop codon of the endogenous gene with an enhanced green fluorescent protein (EFGP) sequence and polyadenylation sequence, followed by a loxP-flanked neomycin resistance (neo) cassette. Cre-mediated recombination removed the floxed neo cassette. (J:218664)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf8 Mutation:	32 strains or lines available

Original:	J:218664 Wang H, et al., A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation. J Immunol. 2014 Aug 15;193(4):1766-77
All:	12 reference(s)