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Hist1tm1Sis
Targeted Allele Detail
Summary
Symbol: Hist1tm1Sis
Name: histone cluster 1; targeted mutation 1, Shunsuke Ishii
MGI ID: MGI:5617502
Synonyms: Th2a-Th2b-
Gene: Hist1  Location: unknown  Genetic Position: Chr13, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:210169
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
  Hist1tm1Sis involves 2 genes/genome features (H2bc1, H2ac1) View all
 
Mutation detailsA 3.7 kb region, which includes exons of both Hist1h2aa and Hist1h2ba as well as the common promoter located between the genes, was replaced with a neo cassette via homologous recombination. (J:210169)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hist1 Mutation:  2 strains or lines available
References
Original:  J:210169 Shinagawa T, et al., Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells. Cell Stem Cell. 2014 Feb 6;14(2):217-27
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory