Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cldn4tm1.1Zboro
Name:	claudin 4; targeted mutation 1.1, Zea Borok
MGI ID:	MGI:5609571
Gene:	Cldn4  Location: Chr5:134973977-134975788 bp, - strand  Genetic Position: Chr5, 74.9 cM
Alliance:	Cldn4tm1.1Zboro page

Germline Transmission:	Earliest citation of germline transmission: J:216793
Parent Cell Line:	W4 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A FRT-flanked neomycin selection cassette and a loxP site were inserted downstream of the single coding exon of the targeted gene, and another loxP site was inserted upstream of the single coding exon. FLP mediated recombination removed the FRT-flanked neo cassette leaving the coding exon floxed. (J:216793)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cldn4 Mutation:	10 strains or lines available

Original:	J:216793 Kage H, et al., Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury. Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1;307(7):L524-36
All:	1 reference(s)