Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Eif4g1tm1.2Mjff
Name:	eukaryotic translation initiation factor 4, gamma 1; targeted mutation 1.2, The Michael J Fox Foundation
MGI ID:	MGI:5607733
Gene:	Eif4g1  Location: Chr16:20491457-20511633 bp, + strand  Genetic Position: Chr16, 12.49 cM
Alliance:	Eif4g1tm1.2Mjff page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The targeting vector was designed (by site-directed mutagenesis) to insert the arginine to histidine amino acid substitution at position 1207 (R1207H) (human 1205) into exon 24 and place a loxP site upstream of exon 24, followed by an FRT-flanked neomycin cassette and a loxP site downstream of exon 28. Flp-mediated recombination removed the neomycin cassette. Cre-mediated recombination removed the floxed exons 24-28. (J:101977)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Eif4g1 Mutation:	62 strains or lines available

Original:	J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:	1 reference(s)