Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Wnt1-rtTA2S*M2)1Whsu
Name:	transgene insertion 1, Wei Hsu
MGI ID:	MGI:5605471
Synonyms:	Wnt1-rtTA
Transgene:	Tg(Wnt1-rtTA2S*M2)1Whsu  Location: unknown
Alliance:	Tg(Wnt1-rtTA2S*M2)1Whsu page

Strain of Origin:

(C57BL/6J x CBA/J)F1

Transgene Type:    Transgenic (Transactivator) Mutation:    Insertion   Mutation details: The transgenic construct contains an modified form of reverse tetracycline-controlled transactivator, under the control of the mouse Wnt1, wingless-type MMTV integration site family, member 1, promoter and enhancer. This version of rtTA contains 5 amino acid changes in the TetR moiety (S12G, E19G, A56P, D148E, and H179R) and a synthetic optimized transactivating domain. This rtTA has reduced basal activity and enhanced doxycycline sensitivity compared to wild-type rtTA. (J:155252)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:155252 Hsu W, et al., Manipulating gene activity in Wnt1-expressing precursors of neural epithelial and neural crest cells. Dev Dyn. 2009 Aug 3;239(1):338-345
All:	2 reference(s)