Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Drd5tm1.1Stl
Name:	dopamine receptor D5; targeted mutation 1.1, Susumu Tonegawa
MGI ID:	MGI:5603762
Synonyms:	D5R flx
Gene:	Drd5  Location: Chr5:38476742-38479868 bp, + strand  Genetic Position: Chr5, 20.4 cM
Alliance:	Drd5tm1.1Stl page

Germline Transmission:	Earliest citation of germline transmission: J:211355
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was introduced 5' of the targeted gene's single exon and an FRT-loxP-(neo-tk)-FRT-loxP (LFNT) cassette was introduced 3'. Cre-mediated recombination excised the neo cassette, leaving the coding region flanked by loxP sites. (J:101977, J:211355)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Drd5 Mutation:	39 strains or lines available

Original:	J:211355 Sarinana J, et al., Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8245-50
All:	3 reference(s)