Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Ttc21btm2c(KOMP)Wtsi
Name:	tetratricopeptide repeat domain 21B; targeted mutation 2c, Wellcome Trust Sanger Institute
MGI ID:	MGI:5587034
Synonyms:	Thm1flox
Gene:	Ttc21b  Location: Chr2:66014671-66086961 bp, - strand  Genetic Position: Chr2, 39.08 cM
Alliance:	Ttc21btm2c(KOMP)Wtsi page
IMPC:	Ttc21b gene page

Mutant Cell Line:	EPD0041_2_E09
Germline Transmission:	Earliest citation of germline transmission: J:213263
Parent Cell Line:	JM8.F6 (ES Cell)
Strain of Origin:	C57BL/6N
Project Collection:	KOMP-CSD

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion     Vector: L1L2_gt1   Mutation details: The L1L2_gt1 cassette was inserted at position 66079515 of Chromosome 2 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 66080377. The critical exon, exon 4, is thus flanked by loxP sites. A "conditional ready" (floxed) allele is created by flp recombinase expression in mice carrying this allele, removing the lacZ/neomycin cassette, but leaving exon 4 flanked by loxP sites. (J:213263)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ttc21b Mutation:	52 strains or lines available

Original:	J:213263 Tran PV, et al., Downregulating hedgehog signaling reduces renal cystogenic potential of mouse models. J Am Soc Nephrol. 2014 Oct;25(10):2201-12
All:	7 reference(s)