Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Shcbp1tm1d(EUCOMM)Wtsi
Name:	Shc SH2-domain binding protein 1; targeted mutation 1d, Wellcome Trust Sanger Institute
MGI ID:	MGI:5582592
Gene:	Shcbp1  Location: Chr8:4785976-4829549 bp, - strand  Genetic Position: Chr8, 2.09 cM, cytoband A1.2
Alliance:	Shcbp1tm1d(EUCOMM)Wtsi page
IMPC:	Shcbp1 gene page

Mutant Cell Line:	EPD0592_2_A06
Germline Transmission:	Earliest citation of germline transmission: J:212898
Parent Cell Line:	JM8A3.N1 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd
Project Collection:	EUCOMM

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P   Mutation details: The L1L2_Bact_P cassette was inserted at position 4798418 of Chromosome 8 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 4800268. The critical exons are thus flanked by loxP sites. The lacZ and neomycin segments were excised with germline Flp recombinase, leaving exons 4 and 6 flanked by loxP sites. Then animals were crossed with a germline Cre strain to delete exons 4 through 6. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:212898)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Shcbp1 Mutation:	42 strains or lines available

Original:	J:212898 Buckley MW, et al., Unexpected Phenotype of Mice Lacking Shcbp1, a Protein Induced during T Cell Proliferation. PLoS One. 2014;9(8):e105576
All:	1 reference(s)