Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prg4tm2Mawa
Name:	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein); targeted mutation 2, Matthew Warman
MGI ID:	MGI:5581510
Synonyms:	Prg4GT, Prg4:GT
Gene:	Prg4  Location: Chr1:150325163-150341916 bp, - strand  Genetic Position: Chr1, 63.84 cM, cytoband G
Alliance:	Prg4tm2Mawa page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Null/knockout, Reporter, Transactivator) Mutation:    Insertion   Mutation details: A targeting vector containing a loxP-flanked artifical exon that contains a strong splice acceptor, an in-frame Bgeo lacZ coding sequence, an internal ribosome entry site (IRES), a reverse tet transactivator (rtTA) cassette with a polyA signal, and a neomycin selection cassette driven by its own promoter was inserted into intron 2 of the gene. The allele does not express wild-type Prg4 mRNA, as determined by RT-PCR. Cre-mediated excision of the targeting vector leaves one loxP in intron 2 and allows expression of Prg4 mRNA. (J:101977)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prg4 Mutation:	71 strains or lines available

Original:	J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:	5 reference(s)