Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc1a2tm1.1Ncd
Name:	solute carrier family 1 (glial high affinity glutamate transporter), member 2; targeted mutation 1.1, NC Danbolt
MGI ID:	MGI:5576462
Synonyms:	EAAT2-flox
Gene:	Slc1a2  Location: Chr2:102489004-102621129 bp, + strand  Genetic Position: Chr2, 54.13 cM
Alliance:	Slc1a2tm1.1Ncd page

Germline Transmission:	Earliest citation of germline transmission: J:207177
Parent Cell Line:	D1 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6J)F1

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted into intron 2 and an frt-neo-frt-loxP cassette was inserted into intron 4, floxing exons 3 and 4 of the Slc1a2 gene from the bacterial artificial chromosome clone RP24-315H4. The neomycin cassette was removed via FLP-mediated recombination, leaving exons 3 and 4 floxed by loxP sites. Cre-mediated recombination can be used to remove exons 3 and 4 which results in a frameshift deletion. (J:207177)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc1a2 Mutation:	40 strains or lines available

Original:	J:207177 Zhou Y, et al., Proteome analysis and conditional deletion of the EAAT2 glutamate transporter provide evidence against a role of EAAT2 in pancreatic insulin secretion in mice. J Biol Chem. 2014 Jan 17;289(3):1329-44
All:	5 reference(s)