Tg(Prnp-Immt/SOD1)1Gmnf
Transgene Detail
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| Symbol: |
Tg(Prnp-Immt/SOD1)1Gmnf |
| Name: |
transgene insertion 1, Giovanni Manfredi |
| MGI ID: |
MGI:5575877 |
| Synonyms: |
mito-SOD1WT, mito-WTSOD1, Prp-mito-WTSOD1 |
| Transgene: |
Tg(Prnp-Immt/SOD1)1Gmnf Location: unknown
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| Alliance: |
Tg(Prnp-Immt/SOD1)1Gmnf page
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Prnp-Immt/SOD1)1Gmnf expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
SOD1 (6647) |
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Mutation details: The mito-WTSOD1 fusion protein contains a mouse mitofilin (Immt) cDNA sequence encoding the first 187 amino acids (including the mitochondrial targeting presequence, MMP cleavage site and transmembrane domain) fused in-frame to the N-terminus of a wild-type human Cu,Zn superoxide dismutase (SOD1) cDNA sequence. The SOD1 start codon was removed and substituted with an in-frame 6 nt DNA linker. This mito-WTSOD1 sequence was inserted between exon 2 and exon 3 of mouse prion protein (PrP or Prnp) gene at a unique XhoI site in the MoPrP.Xho plasmid vector. The founder line with the highest expression level (founder line 1) was characterized.
(J:211695)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:211695 Fischer LR, et al., SOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse. Brain. 2011 Jan;134(Pt 1):196-209 |
| All: |
4 reference(s) |
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Analysis Tools
