Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Lats2tm1.1Jfm
Name:	large tumor suppressor 2; targeted mutation 1.1, James F Martin
MGI ID:	MGI:5568589
Synonyms:	Lats2f
Gene:	Lats2  Location: Chr14:57927119-57983669 bp, - strand  Genetic Position: Chr14, 30.28 cM
Alliance:	Lats2tm1.1Jfm page

Germline Transmission:	Earliest citation of germline transmission: J:170963
Parent Cell Line:	RJ2.2 (ES Cell)
Strain of Origin:	(C57BL/6Brd-Tyrc-Brd x 129S6/SvEvTac)F1

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: A targeting vector was designed to flank exon 5 with loxP sites. This construct also contained a frt-flanked neomycin resistance (neo) cassette. FLP-mediated recombination removed the neo cassette. (J:101977)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

48 assay results 6 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Lats2tm1.1Jfm

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lats2 Mutation:	42 strains or lines available

Original:	J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:	50 reference(s)