Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(HIV-EGFP,luc)8Tsb
Name:	transgene insertion 8, Timothy S Blackwell
MGI ID:	MGI:5568390
Synonyms:	NF-kappaB-GFP-Luciferase (NGL), NLG
Transgene:	Tg(HIV-EGFP,luc)8Tsb  Location: unknown
Alliance:	Tg(HIV-EGFP,luc)8Tsb page

Strain of Origin:

C57BL/6 or DBA/2

Transgene Type:    Transgenic (Reporter) Mutation:    Insertion   Mutation details: Four tandem copies of a 36-base enhancer from the 5' HIV-long terminal repeat (containing two NF-kappaB binding sites, GGGACTTTCC) were placed upstream of the HSV minimal thymidine kinase promoter. This enhancer-promoter construct was used to drive expression of an enhanced GFP-luciferase fusion protein. (J:131182)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:131182 Everhart MB, et al., Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury. J Immunol. 2006 Apr 15;176(8):4995-5005
All:	10 reference(s)