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Pld1tm1.1Gdp
Targeted Allele Detail
Summary
Symbol: Pld1tm1.1Gdp
Name: phospholipase D1; targeted mutation 1.1, Gilbert Di Paolo
MGI ID: MGI:5556064
Synonyms: Pld1tm2.1Mafr
Gene: Pld1  Location: Chr3:27992844-28187511 bp, + strand  Genetic Position: Chr3, 11.15 cM
Alliance: Pld1tm1.1Gdp page
Reduced hepatic autophagy in starved Pld1tm1.1Gdp/Pld1tm1.1Gdp mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:207283
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6 x 129/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 13. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 14. This allele is created by using either Cre-mediated recombination to remove exon 13, exon 14 and the selection cassette or Flp-mediated recombination to remove the FRT-flanked neo cassette, followed by Cre-mediated recombination to remove exons 13 and 14 . Western blot analysis confirmed the absence of protein expression in the liver and mouse embryonic fibroblasts. (J:207283)
Generation of the Pld1tm1.1Gdp allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pld1 Mutation:  64 strains or lines available
References
Original:  J:207283 Dall'Armi C, et al., The phospholipase D1 pathway modulates macroautophagy. Nat Commun. 2010;1:142
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory