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Ubr4tm1.2Nkt
Targeted Allele Detail
Summary
Symbol: Ubr4tm1.2Nkt
Name: ubiquitin protein ligase E3 component n-recognin 4; targeted mutation 1.2, Yoshihiro Nakatani
MGI ID: MGI:5532332
Gene: Ubr4  Location: Chr4:139107970-139216844 bp, + strand  Genetic Position: Chr4, 70.66 cM
Alliance: Ubr4tm1.2Nkt page
Mild growth retardation and brain abnormalities in Ubr4tm1.2Nkt/Ubr4tm1.2Nkt Edil3Tg(Sox2-cre)1Amc/0 embryos

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:203460
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neomycin resistance cassette and left exon 1 floxed. (J:203460)
Generation of the Ubr4tm1.2Nkt allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 10 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ubr4 Mutation:  247 strains or lines available
References
Original:  J:203460 Nakaya T, et al., p600 Plays Essential Roles in Fetal Development. PLoS One. 2013;8(6):e66269
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory