Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ass1tm1.2Ekoe
Name:	argininosuccinate synthetase 1; targeted mutation 1.2, Eleonore Kohler
MGI ID:	MGI:5529836
Gene:	Ass1  Location: Chr2:31360282-31410682 bp, + strand  Genetic Position: Chr2, 21.81 cM
Alliance:	Ass1tm1.2Ekoe page

Germline Transmission:	Earliest citation of germline transmission: J:203474
Parent Cell Line:	IB10/E14IB10 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 13. An additional loxP site was inserted downstream of exon 13. Flpe-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exon 13. (J:203474)

Generation of the Ass1tm1.1Ekoe and Ass1tm1.2Ekoe alleles

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ass1 Mutation:	56 strains or lines available

Original:	J:203474 Marion V, et al., Hepatic adaptation compensates inactivation of intestinal arginine biosynthesis in suckling mice. PLoS One. 2013;8(6):e67021
All:	1 reference(s)