Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Boktm1.1Ast
Name:	BCL2-related ovarian killer; targeted mutation 1.1, Andreas Strasser
MGI ID:	MGI:5527387
Gene:	Bok  Location: Chr1:93613382-93623486 bp, + strand  Genetic Position: Chr1, 47.28 cM
Alliance:	Boktm1.1Ast page

Germline Transmission:	Earliest citation of germline transmission: J:203179
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 1b. An FRT- and loxP-flanked hygromycin resistance cassette was inserted downstream of exon 2. Cre-mediated recombination removed exon 1b, exon 2 and the hygromycin resistance cassette. Western blot analysis confirmed the absence of protein expression in the uterus, rectum, colon, placenta and spleen. (J:203179)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bok Mutation:	21 strains or lines available

Original:	J:203179 Ke F, et al., BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice. Cell Death Differ. 2012 Jun;19(6):915-25
All:	11 reference(s)