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Gene Expression Data
Assay Details
Assay
Reference: J:90276 Ota MS, et al., Twist is required for patterning the cranial nerves and maintaining the viability of mesodermal cells. Dev Dyn. 2004 Jun;230(2):216-28
Assay type: RNA in situ
MGI Accession ID: MGI:5527076
Gene symbol: Sox10
Gene name: SRY (sex determining region Y)-box 10
Probe: Sox10 probe2
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1A: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: dorsal root ganglion Present 1A
TS15: facio-acoustic preganglion complex Present 1A
TS15: glossopharyngeal preganglion Present 1A
TS15: somite Present 1A
TS15: trigeminal preganglion Present 1A
TS15: vagus preganglion Present 1A
TS15: spinal component of peripheral nervous system Present Regionally restricted 1A Expression is is the spinal nerves.
TS15: head mesenchyme Present Regionally restricted 1A Expression is in the mesenchyme around the optic evagination of the forebrain and in the upper facial region.

Specimen 1B: embryonic day 9.5; Twist1tm1Bhr/Twist1tm1Bhr (more )
Structure Level Pattern Image Note
TS15: facio-acoustic preganglion complex Present 1B There is an absence of the separation of the trigeminal and facioacoustic ganglia in the mutant embryo.
TS15: trigeminal preganglion Present 1B There is an absence of the separation of the trigeminal and facioacoustic ganglia in the mutant embryo.
TS15: 1st branchial arch Present Regionally restricted 1B There are two streams of expressing cells extending from the hindbrain to the first and second branchial arches.
TS15: 2nd branchial arch Present Regionally restricted 1B There are two streams of expressing cells extending from the hindbrain to the first and second branchial arches.
TS15: future hindbrain Present Regionally restricted 1B There are two streams of expressing cells extending from the hindbrain to the first and second branchial arches.
TS15: spinal component of peripheral nervous system Present Regionally restricted 1B Expression is is the spinal nerves.
TS15: dorsal root ganglion Present 1B
TS15: head mesenchyme Present Regionally restricted 1B Expression is in the cranial mesenchyme, particularly in the mesenchyme ventral to the rostral part of the open cephalic neural folds and in the maxillary region.
TS15: somite Present Regionally restricted 1B Expression in somites does not extends as far caudally as in wild-type embryos.

Specimen 1C: embryonic day 10.0 (more )
Structure Level Pattern Image Note
TS16: trigeminal ganglion Present 1C
TS16: head mesenchyme Present Regionally restricted 1C Expression is in the mesenchyme around the optic evagination of the forebrain and in the upper facial region.

Specimen 1D: embryonic day 10.0; Twist1tm1Bhr/Twist1tm1Bhr (more )
Structure Level Pattern Image Note
TS16: branchial arch Present Regionally restricted 1D There is extended distribution of expressing cells from the neural folds to the branchial arch in this mutant.
TS16: future brain Present Regionally restricted 1D There is extended distribution of expressing cells from the neural folds to the branchial arch in this mutant.
TS16: 1st branchial arch Present Regionally restricted 1D There is persistent expression in the postmigratory cells in this mutant.

Specimen 1E: embryonic day 10.0; Twist1tm1Bhr/Twist1tm1Bhr (more )
Structure Level Pattern Image Note
TS16: branchial arch Present Regionally restricted 1E There is extended distribution of expressing cells from the neural folds to the branchial arch in this mutant.
TS16: future brain Present Regionally restricted 1E There is extended distribution of expressing cells from the neural folds to the branchial arch in this mutant.
TS16: 2nd branchial arch Present Regionally restricted 1E There is persistent expression in the postmigratory cells in this mutant.

Specimen 1F: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: trunk Present Regionally restricted 1F Segmental expression.

Specimen 1G: embryonic day 9.5; Twist1tm1Bhr/Twist1tm1Bhr (more )
Structure Level Pattern Image Note
TS15: trunk Present Regionally restricted 1G Diffuse expression in the upper trunk.
TS15: trunk paraxial mesenchyme Present Regionally restricted 1G Expression is in the dorsal aspect of the paraxial mesoderm of the lower trunk.
TS15: somite Present Regionally restricted 1G Expression is dorsal.

Specimen 1H: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: dorsal root ganglion Present 1H
TS15: spinal component of peripheral nervous system Present Regionally restricted 1H Expression is is the spinal nerves.

Specimen 1I: embryonic day 9.5; Twist1tm1Bhr/Twist1tm1Bhr (more )
Structure Level Pattern Image Note
TS15: trunk paraxial mesenchyme Present Regionally restricted 1I Dispersed expression.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory