Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Charles L Sawyers
MGI ID:	MGI:5524275
Synonyms:	Rosa26ERG
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key page

Germline Transmission:	Earliest citation of germline transmission: J:200002
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Gt(ROSA)26Sortm1(TMPRSS2/ERG)Key expresses 2 genes Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human ERG (2078) Erg  (MGI:95415) human TMPRSS2 (7113) Tmprss2  (MGI:1354381)   Mutation details: The targeting construct introduced into the locus a splice acceptor sequence, floxed neomycin resistance STOP (4x polyadenylation sequence) cassette, fusion of human TMPRSS2 (exon 1) and ERG (exon 4), IRES, nuclear localized EGFP and polyadenylation sequence. (J:200002)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:200002 Chen Y, et al., ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss. Nat Med. 2013 Aug;19(8):1023-9
All:	8 reference(s)