Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lin28atm1.2Gqda
Name:	lin-28 homolog A; targeted mutation 1.2, George Q Daley
MGI ID:	MGI:5519953
Gene:	Lin28a  Location: Chr4:133730641-133746152 bp, - strand  Genetic Position: Chr4, 66.5 cM
Alliance:	Lin28atm1.2Gqda page

Germline Transmission:	Earliest citation of germline transmission: J:177113
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 2. An FRT flanked neo cassette with a 5' loxP site was inserted downstream of exon 2 via homologous recombination. FLP-mediated recombination removed the neomycin cassette. (J:101977, J:177113)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lin28a Mutation:	76 strains or lines available

Original:	J:177113 Zhu H, et al., The Lin28/let-7 Axis Regulates Glucose Metabolism. Cell. 2011 Sep 30;147(1):81-94
All:	10 reference(s)