Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bcl6tm1.1Dent
Name:	B cell leukemia/lymphoma 6; targeted mutation 1.1, Alexander Dent
MGI ID:	MGI:5518542
Synonyms:	Bcl6fl
Gene:	Bcl6  Location: Chr16:23783802-23807602 bp, - strand  Genetic Position: Chr16, 15.26 cM
Alliance:	Bcl6tm1.1Dent page

Germline Transmission:	Earliest citation of germline transmission: J:202372
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert a single loxP site upstream of exon 7, and a loxP-flanked neomycin resistance (neo) cassette downstream of exon 9. Exons 7-9 encode the zinc finger domain. The neo selection cassette was subsequently removed from properly targeted mice by crossing to transgenic mice carrying Tg(EIIa-cre)C5379Lmgd. (J:202372)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Bcl6 Mutation:	55 strains or lines available

Original:	J:202372 Hollister K, et al., Insights into the role of Bcl6 in follicular Th cells using a new conditional mutant mouse model. J Immunol. 2013 Oct 1;191(7):3705-11
All:	61 reference(s)