Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kdm1atm1.1Sho
Name:	lysine (K)-specific demethylase 1A; targeted mutation 1.1, Stuart Orkin
MGI ID:	MGI:5514399
Synonyms:	LSD1fl/fl
Gene:	Kdm1a  Location: Chr4:136277851-136330034 bp, - strand  Genetic Position: Chr4, 68.8 cM
Alliance:	Kdm1atm1.1Sho page

Germline Transmission:	Earliest citation of germline transmission: J:201572
Parent Cell Line:	CJ9 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert a single loxP site followed by a frt-flanked neomycin resistance (neo) cassette upstream of exon 5, and a second loxP site downstream of exon 6. Exons 5 and 6 encode a flavin adenine dinucleotide binding site and the N-terminal portion of the amine oxidase domain, both required for enzymatic activity. FLPe-mediated recombination removed the selection cassette. (J:201572)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kdm1a Mutation:	39 strains or lines available

Original:	J:201572 Kerenyi MA, et al., Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation. Elife. 2013;2:e00633
All:	16 reference(s)