Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Amfrtm1.1Amw
Name:	autocrine motility factor receptor; targeted mutation 1.1, Allan M Weissman
MGI ID:	MGI:5509334
Synonyms:	gp78-
Gene:	Amfr  Location: Chr8:94698216-94739301 bp, - strand  Genetic Position: Chr8, 45.96 cM
Alliance:	Amfrtm1.1Amw page

Germline Transmission:	Earliest citation of germline transmission: J:200251
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT and loxP flanked neomycin resistance cassette was inserted upstream of exon 7. An additional loxP site was inserted downstream of exon 8. Cre-mediated recombination removed the neomycin resistance cassette, exon 7 and exon 8. Western blot analysis confirmed the absence of protein in mouse embronic fibroblasts. (J:200251)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Amfr Mutation:	42 strains or lines available

Original:	J:200251 Tsai YC, et al., Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system. Mol Biol Cell. 2012 Dec;23(23):4484-94
All:	1 reference(s)