Tg(UBC-CCR5,-CD4)19Mnz
Transgene Detail
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Symbol: |
Tg(UBC-CCR5,-CD4)19Mnz |
Name: |
transgene insertion 19, Michel C Nussenzweig |
MGI ID: |
MGI:5509007 |
Transgene: |
Tg(UBC-CCR5,-CD4)19Mnz Location: unknown
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Alliance: |
Tg(UBC-CCR5,-CD4)19Mnz page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(UBC-CCR5,-CD4)19Mnz expresses
2 genes
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
CCR5 (1234) |
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human |
CD4 (920) |
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Mutation details: A transgene composed of human CCR5 and CD4 on a single poly-protein transcript separated by a ribosomal skip 2A was placed downstream of thehuman ubiquitin C promoter. A linearized 4.5 Kb fragment containing the transgene was injected into C57BL/6J fertilized female pronuclei. Founder line 19 was chosen based on surface expression of hCD4 and hCCR5 on peripheral blood mononuclear cells as determined by flow cytometry.
(J:200013)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:200013 Gruell H, et al., Antibody and antiretroviral preexposure prophylaxis prevent cervicovaginal HIV-1 infection in a transgenic mouse model. J Virol. 2013 Aug;87(15):8535-44 |
All: |
1 reference(s) |
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