Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prmt6tm1.2Rchd
Name:	protein arginine N-methyltransferase 6; targeted mutation 1.2, Stephane Richard
MGI ID:	MGI:5508653
Gene:	Prmt6  Location: Chr3:110153425-110158314 bp, - strand  Genetic Position: Chr3, 48.52 cM
Alliance:	Prmt6tm1.2Rchd page

Germline Transmission:	Earliest citation of germline transmission: J:199753
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 1. A loxP- and FRT-flanked neomycin resistance cassette was inserted downstream of exon 1. Flp-mediated recombination removed the neomycin resistance cassette and left exon 1 floxed. Cre-mediated recombination removed exon 1. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:199753)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

12 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prmt6 Mutation:	19 strains or lines available

Original:	J:199753 Neault M, et al., Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor. Nucleic Acids Res. 2012 Oct;40(19):9513-21
All:	4 reference(s)