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Pappa2tm1.1Jkcs
Targeted Allele Detail
Summary
Symbol: Pappa2tm1.1Jkcs
Name: pappalysin 2; targeted mutation 1.1, Julian K Christians
MGI ID: MGI:5504500
Gene: Pappa2  Location: Chr1:158539297-158788019 bp, - strand  Genetic Position: Chr1, 68.49 cM
Alliance: Pappa2tm1.1Jkcs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:199327
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the neomycin resistance cassette. (J:199327)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pappa2 Mutation:  87 strains or lines available
References
Original:  J:199327 Christians JK, et al., Pregnancy associated plasma protein A2 (PAPP-A2) affects bone size and shape and contributes to natural variation in postnatal growth in mice. PLoS One. 2013;8(2):e56260
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory