Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Nf2tm2Gvn
Name:	neurofibromin 2; targeted mutation 2, Marco Giovannini
MGI ID:	MGI:5504370
Synonyms:	Nf2-iso2-
Gene:	Nf2  Location: Chr11:4715845-4799536 bp, - strand  Genetic Position: Chr11, 3.0 cM
Alliance:	Nf2tm2Gvn page

Germline Transmission:	Earliest citation of germline transmission: J:197562
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Modified isoform(s)) Mutation:    Not Specified   Mutation details: An isoform 2-specific knock-out was generated. Western blot analysis confirmed reduced neurofilament phosphorylation in the brain. (J:197562)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Nf2tm2Gvn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nf2 Mutation:	65 strains or lines available

Original:	J:197562 Schulz A, et al., Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy. Nat Neurosci. 2013 Apr;16(4):426-33
All:	3 reference(s)