Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Eif2ak3tm1.2Drc
Name:	eukaryotic translation initiation factor 2 alpha kinase 3; targeted mutation 1.2, Douglas R Cavener
MGI ID:	MGI:5502572
Gene:	Eif2ak3  Location: Chr6:70821499-70882229 bp, + strand  Genetic Position: Chr6, 32.09 cM
Alliance:	Eif2ak3tm1.2Drc page

Germline Transmission:	Earliest citation of germline transmission: J:76661
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Two loxP sites were introduced to intronic regions flanking the three exons encoding part of the lumenal domain, the transmembrane domain, and part of the catalytic domain. A third loxP site was introduced with a PGK-neo cassette directly downstream of the second loxP site in the same intron. Cre-mediated recombination removed the neo cassette and left the three exons floxed. (J:76661)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Eif2ak3 Mutation:	51 strains or lines available

Original:	J:76661 Zhang P, et al., The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol. 2002 Jun;22(11):3864-74
All:	31 reference(s)