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Gene Expression Data
Assay Details
Assay
Reference: J:110707 Pattyn A, et al., Delays in neuronal differentiation in Mash1/Ascl1 mutants. Dev Biol. 2006 Jul 1;295(1):67-75
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5495266
Gene symbol: Lmx1b
Gene name: LIM homeobox transcription factor 1 beta
Antibody: Anti-Lmx1b
Detection system: Texas Red
Results
Specimen 2D WT: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: hindbrain Present Regionally restricted 2D WT Expression in nucleus of solitary tract (nTS) and area postrema (ap).
Specimen 2D Mash1-/-: embryonic day 10.5; Ascl1tm1And/Ascl1tm1And (more )
Structure Level Pattern Image Note
TS17: hindbrain Absent 2D Mash1-/- Authors state that nucleus of solitary tract precursors (nTSp) are not detected. Hindbrain dl5 neurons are also absent.
Specimen 2G WT: embryonic day 11.5 (more )
Note: Double labeled: red - Lmx1b; green - Phox2b (assay MGI:5495267).
Structure Level Pattern Image Note
TS19: hindbrain Present Regionally restricted 2G WT Expression in nucleus of solitary tract (nTS) and area postrema (ap).
Specimen 2G Mash1-/-: embryonic day 11.5; Ascl1tm1And/Ascl1tm1And (more )
Note: Double labeled: red - Lmx1b; green - Phox2b (assay MGI:5495267).
Structure Level Pattern Image Note
TS19: hindbrain Present Regionally restricted 2G Mash1-/- Few nucleus of solitary tract precursors (nTSp) are detectable, but no dl5 neurons.
Specimen 2H WT: embryonic day 12.5 (more )
Note: Double labeled: red - Lmx1b; green - Phox2b (assay MGI:5495267).
Structure Level Pattern Image Note
TS20: hindbrain Present Regionally restricted 2H WT Expression in nucleus of solitary tract (nTS) and area postrema (ap).
Specimen 2H Mash1-/-: embryonic day 12.5; Ascl1tm1And/Ascl1tm1And (more )
Note: Double labeled: red - Lmx1b; green - Phox2b (assay MGI:5495267).
Structure Level Pattern Image Note
TS20: hindbrain Weak Regionally restricted 2H Mash1-/- Expression in an increasing amount of nucleus of solitary tract (nTS) neurons, although in greatly reduced numbers compared to controls.
Specimen 4C WT E10.5: embryonic day 10.5 (more )
Note: Double labeled: red - Lmx1b; green - Phox2b (assay MGI:5495267).
Structure Level Pattern Image Note
TS17: hindbrain Present Regionally restricted 4C WT E10.5
Specimen 4C WT E12: embryonic day 12.0 (more )
Note: Double labeled: red - Lmx1b; green - Phox2b (assay MGI:5495267).
Structure Level Pattern Image Note
TS20: hindbrain Present Regionally restricted 4C WT E12
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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