Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Albem8Mvw
Name:	albumin; endonuclease-mediated mutation 8, Michael Wiles
MGI ID:	MGI:5494601
Synonyms:	Alb-
Gene:	Alb  Location: Chr5:90608756-90624461 bp, + strand  Genetic Position: Chr5, 44.7 cM
Alliance:	Albem8Mvw page

Strain of Origin:

C57BL/6J

Allele Type:    Endonuclease-mediated (Null/knockout) Mutations:    Intragenic deletion, Single point mutation   Mutation details: Exon 4 was targeted by introduction of TALEN mRNA into fertilized C57BL/6J oocytes and the resulting founder screened and found to have a 1 base pair deletion at Chromosome 5 base 90,464,113 (GRCm38.p2) which is predicted to result in a frame shift then a premature stop codon 55 amino acids downstream of the encoded frame shift. By ELISA, heterozgyotes have a decrease in serum albumin of approximately 30 percent and homozygotes have no detectable serum albumin. (J:220803)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Alb Mutation:	91 strains or lines available

Original:	J:220803 Roopenian DC, et al., Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs. MAbs. 2015;7(2):344-51
All:	6 reference(s)