Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol: Cd28tm1Ltu Name: CD28 antigen; targeted mutation 1, Laurence A Turka MGI ID: MGI:5485211 Synonyms: Cd28fl Gene: Cd28  Location: Chr1:60785547-60812521 bp, + strand  Genetic Position: Chr1, 30.52 cM, cytoband C1-C3 Alliance: Cd28tm1Ltu page

Skin inflammation and enlarged lymph nodes and spleen in Cd28tm1Ltu/Cd28tm1Ltu Foxp3tm4(YFP/icre)Ayr/Foxp3+ mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:194503
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. (J:194503)

Generation of the Cd28tm1Ltu allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd28 Mutation:	53 strains or lines available

Original:	J:194503 Zhang R, et al., An obligate cell-intrinsic function for CD28 in Tregs. J Clin Invest. 2013 Feb;123(2):580-93
All:	6 reference(s)