Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Nuggctm1.2Diaz
Name:	nuclear GTPase, germinal center associated; targeted mutation 1.2, Marilyn Diaz
MGI ID:	MGI:5476765
Gene:	Nuggc  Location: Chr14:65835995-65885980 bp, + strand  Genetic Position: Chr14, 34.34 cM
Alliance:	Nuggctm1.2Diaz page

Germline Transmission:	Earliest citation of germline transmission: J:190402
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 4. Cre-mediated recombination removed the neo cassette and left exons 2 through 4 floxed. (J:190402)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nuggc Mutation:	47 strains or lines available

Original:	J:190402 Richter K, et al., Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein. J Biol Chem. 2012 Sep 14;287(38):31856-65
All:	1 reference(s)