About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:48134 Grigoriou M, et al., Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development. Development. 1998 Jun;125(11):2063-74
Assay type: RNA in situ
MGI Accession ID: MGI:5473824
Gene symbol: Lhx8
Gene name: LIM homeobox protein 8
Probe: Lhx7 cDNA4
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen not shown E9.5: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: 1st branchial arch Weak Regionally restricted Low levels first detected in a subdomain of the first branchial arch.

Specimen 3B: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch Strong Regionally restricted 3B High levels of expression restricted to subdomains of the first branchial arch.

Specimen 3D: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mandibular component Present Regionally restricted 3D Expression in oral (future odontogenic) aspect of mandibular process and part of maxillary process, subdomains bordering the cleft separating the two facial primordia.
TS17: 1st branchial arch maxillary component Present Regionally restricted 3D Expression in oral (future odontogenic) aspect of mandibular process and part of maxillary process, subdomains bordering the cleft separating the two facial primordia.

Specimen 3F: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mandibular component mesenchyme derived from neural crest Present 3F
TS17: 1st branchial arch maxillary component mesenchyme derived from neural crest Present 3F
TS17: oral epithelium Absent 3F

Specimen not shown E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: 1st branchial arch Present Regionally restricted Authors report expression in a pattern similar to that of the previous stage.

Specimen 4B: embryonic day 12.5 (more )
Note: Tooth germ stage.
Structure Level Pattern Image Note
TS20: jaw primordium mesenchyme Present Uniform 4B Uniform expression in ectomesenchyme adjoining the oral epithelium.
TS20: oral epithelium Absent 4B

Specimen 4D: embryonic day 13.5 (more )
Note: Tooth bud stage.
Structure Level Pattern Image Note
TS21: lower jaw mesenchyme Present Regionally restricted 4D Expression downregulated in most regions of maxillary and mandibular mesenchyme, but maintained and/or upregulated in mesenchyme adjacent to epithelial thickenings constituting the tooth primordia.
TS21: upper jaw mesenchyme Present Regionally restricted 4D Expression downregulated in most regions of maxillary and mandibular mesenchyme, but maintained and/or upregulated in mesenchyme adjacent to epithelial thickenings constituting the tooth primordia.
TS21: oral epithelium Absent 4D

Specimen 4F: embryonic day 14.5 (more )
Note: Cap stage.
Structure Level Pattern Image Note
TS22: tooth mesenchyme Strong 4F At subsequent stages, high levels of expression restricted to mesenchymal component of developing tooth.
TS22: tooth epithelium Absent 4F

Specimen 5D: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: telencephalon Present Regionally restricted 5D Expression in the medial ganglionic eminence, mainly in the submantle and mantle zones. No expression in the lateral ganglionic eminence.

Specimen 5E: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: medial ganglionic eminence Present Regionally restricted 5E Expression in the medial ganglionic eminence, mainly in the submantle and mantle zones.
TS21: lateral ganglionic eminence Absent 5E

Specimen 5F: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: medial ganglionic eminence Present Regionally restricted 5F Expression in the medial ganglionic eminence, mainly in the submantle and mantle zones.
TS23: lateral ganglionic eminence Absent 5F

Specimen 7B: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: 1st branchial arch mesenchyme Present Regionally restricted 7B Expression in mediolateral domain underlying oral epithelium of first branchial arch.

Specimen 7I: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: forebrain Present Regionally restricted 7I Domain of expression extends up to a group of cells expressing Fgff8 in the midline of the basal forebrain.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/21/2024
MGI 6.23
The Jackson Laboratory