Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Sh3gl3tm1.1Itl
Name:	SH3-domain GRB2-like 3; targeted mutation 1.1, inGenious Targeting Laboratory
MGI ID:	MGI:5468727
Gene:	Sh3gl3  Location: Chr7:81824581-81956618 bp, + strand  Genetic Position: Chr7, 47.15 cM, cytoband D2-3
Alliance:	Sh3gl3tm1.1Itl page

Germline Transmission:	Earliest citation of germline transmission: J:178947
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6J x 129S1/Sv

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A conditional targeting vector was made by flanking a 1.8kb region containing exon 1 with loxP sites and inserting an FRT site-flanked neomycin-loxP cassette in reverse transcriptional orientation into intron 1. Flp-mediated recombination removed the neo cassette. (J:178947)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sh3gl3 Mutation:	17 strains or lines available

Original:	J:178947 Milosevic I, et al., Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission. Neuron. 2011 Nov 17;72(4):587-601
All:	3 reference(s)