Summary | Transgene origin | Transgene description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	FanceTg(Tyr)2364E-2a2Ove
Name:	Fanconi anemia, complementation group E; transgene insertion 2364E-2a2, Paul Overbeek
MGI ID:	MGI:5467996
Synonyms:	FanceTg(Tyr)OVE2364E-2a2Chfu
Gene:	Fance  Location: Chr17:28532504-28545548 bp, + strand  Genetic Position: Chr17, 14.65 cM
Alliance:	FanceTg(Tyr)2364E-2a2Ove page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: The Tyrosinase minigene is composed of the mouse Tyr enhancer region (623 bp), promoter region (657 bp), and 1566 bp cDNA sequence (including the stop codon). The Tyro minigene is followed by an internal ribosome entry site (IRES) ending with ATGs in all three reading frames (3xATG), an artificial splice donor sequence, and a loxP site. Using inverse PCR analysis, the lentiviral integration site was identified in intron 8 of the Fanconi anemia E gene (Fance) on chromosome 17. The 3'-LTR is linked to the (+) strand of DNA at position 28,458,210 bp [NCB137/mm9; 3'-28,458,210(+)]. (J:251511)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

List all tumor models in MMHCdb carrying FanceTg(Tyr)2364E-2a2Ove

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fance Mutation:	21 strains or lines available

Original:	J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015;
All:	6 reference(s)