Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pou4f3tm1.1(HBEGF)Jsto
Name:	POU domain, class 4, transcription factor 3; targeted mutation 1.1, Jennifer S Stone
MGI ID:	MGI:5467563
Synonyms:	Pou4f3DTR
Gene:	Pou4f3  Location: Chr18:42527662-42529158 bp, + strand  Genetic Position: Chr18, 22.58 cM, cytoband B3-E1
Alliance:	Pou4f3tm1.1(HBEGF)Jsto page

Germline Transmission:	Earliest citation of germline transmission: J:191218
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6 x C3H

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Pou4f3tm1.1(HBEGF)Jsto expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human HBEGF (1839) Hbegf  (MGI:96070)   Mutation details: The full coding region of human diphtheria toxin receptor (HBEGF) and a floxed neo cassette were inserted upstream of the translation initiation site. Cre-mediated recombination removed the neo cassette. (J:191218)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pou4f3 Mutation:	25 strains or lines available

Original:	J:191218 Golub JS, et al., Hair cell replacement in adult mouse utricles after targeted ablation of hair cells with diphtheria toxin. J Neurosci. 2012 Oct 24;32(43):15093-105
All:	18 reference(s)