Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Lrrk2tm2.1Mjff
Name:	leucine-rich repeat kinase 2; targeted mutation 2.1, The Michael J Fox Foundation
MGI ID:	MGI:5466852
Synonyms:	Lrrk2T1348N
Gene:	Lrrk2  Location: Chr15:91557378-91700323 bp, + strand  Genetic Position: Chr15, 46.07 cM, cytoband F1
Alliance:	Lrrk2tm2.1Mjff page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	JM8 (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Humanized sequence) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A targeting vector was designed to introduce a threonine to asparagine (T1348N) substitution at codon 1348 in exon 29 of the endogeneous locus. In addition, an FRT-flanked neomycin resistance (neo) cassette was introduced approximately 200 bp downstream of exon 29. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:101977)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrrk2 Mutation:	156 strains or lines available

Original:	J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:	1 reference(s)