Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Esr1tm4.2Ksk
Name:	estrogen receptor 1 (alpha); targeted mutation 4.2, Kenneth S Korach
MGI ID:	MGI:5465426
Synonyms:	Ex3alphaERKO, Ex3-ERKO
Gene:	Esr1  Location: Chr10:4561989-4955633 bp, + strand  Genetic Position: Chr10, 2.03 cM
Alliance:	Esr1tm4.2Ksk page

Germline Transmission:	Earliest citation of germline transmission: J:191182
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed TK-neo selection cassette was inserted downstream of exon 3 and a third loxP site was inserted upstream. The selection cassette and exon 3 were subsequently removed from properly targeted mice by cre excision. (J:191182)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Esr1 Mutation:	67 strains or lines available

Original:	J:191182 Hewitt SC, et al., Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene. FASEB J. 2010 Dec;24(12):4660-7
All:	23 reference(s)