Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Chpftm1.2Hwat
Name:	chondroitin polymerizing factor; targeted mutation 1.2, Hideto Watanabe
MGI ID:	MGI:5464019
Gene:	Chpf  Location: Chr1:75451213-75455951 bp, - strand  Genetic Position: Chr1, 39.14 cM
Alliance:	Chpftm1.2Hwat page

Germline Transmission:	Earliest citation of germline transmission: J:191659
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette and cre-mediated recombination removed exon 1. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:191659)

Generation of the Chpftm1.1Hwat and Chpftm1.2Hwat alleles

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chpf Mutation:	30 strains or lines available

Original:	J:191659 Ogawa H, et al., Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development. PLoS One. 2012;7(8):e43806
All:	1 reference(s)