Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Serpina3gtm1.1Arp
Name:	serine (or cysteine) peptidase inhibitor, clade A, member 3G; targeted mutation 1.1, Philip Ashton-Rickardt
MGI ID:	MGI:5450829
Synonyms:	Serpina3gdelta, Serpina3gtm1.1Dowo
Gene:	Serpina3g  Location: Chr12:104202504-104208198 bp, + strand  Genetic Position: Chr12, 53.71 cM, cytoband F1
Alliance:	Serpina3gtm1.1Arp page

Germline Transmission:	Earliest citation of germline transmission: J:189782
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	C57BL/6J

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 4. A floxed neo cassette was inserted downstream of exon 4. Cre-mediated recombination removed exon 4 and the neo cassette. Experiments confirmed the absence of transcript expression in splenocytes. (J:195889)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Serpina3g Mutation:	26 strains or lines available

Original:	J:189782 Byrne SM, et al., Cathepsin B controls the persistence of memory CD8+ T lymphocytes. J Immunol. 2012 Aug 1;189(3):1133-43
All:	2 reference(s)