Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm4(CAG-EGFP*)Nat
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Jeremy Nathans
MGI ID:	MGI:5449932
Synonyms:	Gt(ROSA)26tm1(CAG-LSL-MitoGFP-3xV5)Nat, mitoEGFP
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm4(CAG-EGFP*)Nat page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, Reporter) Mutation:    Insertion   Mutation details: A targeting vector containing (from 5' to 3') a CAG promoter, a loxP-flanked transcription STOP cassette, the N-terminal 25 amino acid mitochondrial-targeting sequence of cytochrome c oxidase VIIIa (C8a), EGFP fused to a C-terminal triple V5 epitope, a bovine growth hormone 3' UTR, and a Frt-PGKneo-Frt cassette was inserted into the locus. (J:254093)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:254093 Agarwal A, et al., Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017 Feb 8;93(3):587-605.e7
All:	2 reference(s)