Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Arfgef2tm1Itl
Name:	ADP ribosylation factor guanine nucleotide exchange factor 2; targeted mutation 1, inGenious Targeting Laboratory
MGI ID:	MGI:5440903
Gene:	Arfgef2  Location: Chr2:166647508-166739972 bp, + strand  Genetic Position: Chr2, 87.22 cM
Alliance:	Arfgef2tm1Itl page

Germline Transmission:	Earliest citation of germline transmission: J:187673
Parent Cell Line:	iTL BA1 (ES Cell)
Strain of Origin:	(C57BL/6NTac x 129S6/SvEvTac)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 through 5 were replaced with an FRT- and loxP flanked neo cassette. Western blot analysis confirmed the absence of protein expression in the brain. (J:187673)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arfgef2 Mutation:	90 strains or lines available

Original:	J:187673 Zhang J, et al., Brefeldin A-inhibited Guanine Exchange Factor 2 Regulates Filamin A Phosphorylation and Neuronal Migration. J Neurosci. 2012 Sep 5;32(36):12619-29
All:	1 reference(s)