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Tg(HLA-B*0702)#Chmb
Transgene Detail
Summary
Symbol: Tg(HLA-B*0702)#Chmb
Name: transgene insertion, Jeffrey S Chamberlain
MGI ID: MGI:5440508
Transgene: Tg(HLA-B*0702)#Chmb  Location: unknown  
Alliance: Tg(HLA-B*0702)#Chmb page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe human major histocompatibility complex (MHC) class I heavy chain (alpha chain) is encoded by the human leukocyte antigen B gene (HLA-B). In humans, the HLA-B7 serotype defined by the HLA-B*0702 allele is expressed in 15-20% of the population. The transgene used human HLA-B7 genomic clone pJY150 to isolate a 6.0 kbp EcoRI-BamHI fragment (fragment a) encoding the human HLA-B*0702 heavy chain sequence (alpha1, alpha2, alpha3 , transmembrane, and cytoplasmic domains from HLA-B*0702) with 0.66 kbp of 5' flanking DNA and 2.0 kbp of 3' flanking DNA. (J:80781)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
The transgene was microinjected into the male pronucleus of fertilized one-cell embryos (either (B6SJL)F1/J, (B6SJL)F2/J or (B6D2)F1/J).
References
Original:  J:188404 Antal Z, et al., Beyond HLA-A*0201: new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes. J Immunol. 2012 Jun 1;188(11):5766-75
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory