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Gene Expression Data
Assay Details
Assay
Reference: J:137604 Minaki Y, et al., Identification of a novel transcriptional corepressor, Corl2, as a cerebellar Purkinje cell-selective marker. Gene Expr Patterns. 2008 Jul;8(6):418-23
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5436306
Gene symbol: Skor2
Gene name: SKI family transcriptional corepressor 2
Antibody: anti-Corl2
Results
Specimen 1D: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cerebellum primordium Strong 1D
TS20: medulla oblongata Strong 1D
TS20: metencephalon Present Scattered 1D Expression is present in the ventral metencephalon.

Specimen Not shown: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: diencephalon Present Scattered Expression is present in the ventral diencephalon.
TS20: midbrain Present Scattered
TS20: spinal cord Present Scattered

Specimen 2A: embryonic day 12.5 (more )
Note: Double labeled: red - Skor2; green - Sox2 (assay MGI:5436315).
Structure Level Pattern Image Note
TS20: cerebellum primordium Present Regionally restricted 2A , 2A' As demonstrated by double-labeling, expression is present in postmitotic, differentiating neurons, not in the neural progenitor cells. These cells are located just outside the ventricular zone.

Specimen 2B: embryonic day 12.5 (more )
Note: Double labeled: red - Skor2; green - Elav3 (assay MGI:5436316) and Elav4 (assay MGI:5436404).
Structure Level Pattern Image Note
TS20: cerebellum primordium Present Regionally restricted 2B , 2B' As demonstrated by double-labeling, expression is present in postmitotic, differentiating neurons, not in the neural progenitor cells.

Specimen 2C: embryonic day 12.5 (more )
Note: Triple labeled: red - Skor2; blue - Ptf1a (assay MGI:5436321); green - Lhx1 (assay MGI:5436319) and Lhx5 (assay MGI:5436403).
Structure Level Pattern Image Note
TS20: cerebellum primordium Present Regionally restricted 2C , 2C' Expression is present in postmitotic, differentiating neurons, not in the neural progenitor cells. These cells are located just outside the ventricular zone. Double-labeling demonstrated these are GABAergic neurons generated from the c2 domain.

Specimen 2D: embryonic day 12.5 (more )
Note: Double labeled: red - Skor2; green - Gad2 (assay MGI:5436318).
Structure Level Pattern Image Note
TS20: cerebellum primordium Present Regionally restricted 2D , 2D' Expression is present in postmitotic, differentiating neurons, not in the neural progenitor cells. Double-labeling demonstrated these are GABAergic neurons generated from the c2 domain.

Specimen 3A: postnatal adult (more )
Note: Double labeled: red - Skor2; green - Calb1 (assay MGI:5436313).
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present 3A , 3A''
TS28: cerebellum granule cell layer Absent 3A'' , 3A
TS28: cerebellum molecular layer Absent 3A'' , 3A

Specimen 3B: postnatal adult (more )
Note: Double labeled: red - Skor2; green - Calb1 (assay MGI:5436313).
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present 3B
TS28: cerebellum granule cell layer Absent 3B
TS28: cerebellum molecular layer Absent 3B

Specimen Not shown: postnatal adult (more )
Structure Level Pattern Image Note
TS28: deep cerebellar nucleus Absent

Specimen 4A: embryonic day 17.5 (more )
Note: Double labeled: red - Skor2; green - Rora (assay MGI:5436311).
Structure Level Pattern Image Note
TS25: cerebellum Present Regionally restricted 4A'' , 4A''' , 4A As demonstrated by double-labeling, expression is present in developing Purkinje cells.

Specimen 4B: embryonic day 17.5 (more )
Note: Double labeled: red - Skor2; green - Calb1 (assay MGI:5436313).
Structure Level Pattern Image Note
TS25: cerebellum Present Regionally restricted 4B''' , 4B'' , 4B As demonstrated by double-labeling, expression is present in developing Purkinje cells.

Specimen 4D: embryonic day 15.5 (more )
Note: Double labeled: red - Skor2; green - Rora (assay MGI:5436311).
Structure Level Pattern Image Note
TS23: cerebellum Present Regionally restricted 4D'' , 4D , 4D''' As demonstrated by double-labeling, expression is present in developing Purkinje cells.

Specimen 4E: embryonic day 15.5 (more )
Note: Double labeled: red - Skor2; green - Calb1 (assay MGI:5436313).
Structure Level Pattern Image Note
TS23: cerebellum Present Regionally restricted 4E , 4E'' , 4E''' As demonstrated by double-labeling, expression is present in developing Purkinje cells.

Specimen Not shown: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: cerebellum primordium Absent

Specimen 5A: embryonic day 12.5 (more )
Note: Triple labeled: red - Skor2; blue - Ptf1a (assay MGI:5436321); green - Lhx1 (assay MGI:5436319) and Lhx5 (assay MGI:5436403).
Structure Level Pattern Image Note
TS20: cerebellum primordium Present Regionally restricted 5A' , 5A Expression is present in neurons in the dorsal c2 domain. It is believed these cells are Purkinje cells.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory