Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Apctm1.1Klne
Name:	APC, WNT signaling pathway regulator; targeted mutation 1.1, Kristi L Neufeld
MGI ID:	MGI:5431889
Synonyms:	ApcmNLS
Gene:	Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM
Alliance:	Apctm1.1Klne page

Germline Transmission:	Earliest citation of germline transmission: J:186132
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted Mutations:    Insertion, Intragenic deletion   Mutation details: Nucleotide substitutions replaced six amino acids in two nuclear localization sequences (NLS1 and NLS2) by substitution of alanine for lysine. A self-excising neo cassette was inserted into the last intron and removed itself properly. (J:186132)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

List all tumor models in MMHCdb carrying Apctm1.1Klne

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:	154 strains or lines available

Original:	J:186132 Zeineldin M, et al., A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression. Oncogene. 2012 May 10;31(19):2423-37
All:	3 reference(s)