Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Apc2tm1Mno
Name:	APC regulator of WNT signaling pathway 2; targeted mutation 1, Masaharu Noda
MGI ID:	MGI:5428211
Gene:	Apc2  Location: Chr10:80131811-80154097 bp, + strand  Genetic Position: Chr10, 39.72 cM, cytoband B5-C2
Alliance:	Apc2tm1Mno page

Germline Transmission:	Earliest citation of germline transmission: J:184856
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A construct containing an eGFP gene and an inverted neo cassette was inserted in frame in exon 2 after the initiation codon via homologous recombination. RT-PCR and western blot analysis confirmed the absence of expression in the brains of homozygous mice. EGFP expression was detected by RT-PCR and live fluorescent imaging in the nervous system and liver. (J:184856)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apc2 Mutation:	68 strains or lines available

Original:	J:184856 Shintani T, et al., Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2. J Neurosci. 2012 May 9;32(19):6468-84
All:	5 reference(s)