Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bdnftm1.1Krj
Name:	brain derived neurotrophic factor; targeted mutation 1.1, Kevin R Jones
MGI ID:	MGI:5427360
Synonyms:	BDNF-LacZ
Gene:	Bdnf  Location: Chr2:109505045-109557352 bp, + strand  Genetic Position: Chr2, 56.63 cM
Alliance:	Bdnftm1.1Krj page

Germline Transmission:	Earliest citation of germline transmission: J:184139
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 5 and a trimerized downstream polyadenylation signal were removed by cre excision. The resulting mice are expected to express lacZ in place of Bdnf. (J:184139)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

8 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bdnf Mutation:	39 strains or lines available

Original:	J:184139 Kaneko M, et al., Dendritic BDNF synthesis is required for late-phase spine maturation and recovery of cortical responses following sensory deprivation. J Neurosci. 2012 Apr 4;32(14):4790-802
All:	3 reference(s)