Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm50(HTT)Arte
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 50, TaconicArtemis
MGI ID:	MGI:5426930
Synonyms:	N463-Q148
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm50(HTT)Arte page

Germline Transmission:	Earliest citation of germline transmission: J:147112
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inserted expressed sequence, RMCE-ready) Mutation:    Insertion   Gt(ROSA)26Sortm50(HTT)Arte expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human HTT (3064) Htt  (MGI:96067) Expresses human HTT (145Q) truncated at position aa A463   Mutation details: A cDNA construct carrying mutant human Huntington gene (145Q) truncated at position aa A463 (calpainII site) under the control of the CMV early enhancer/chicken beta actin promoter was targeted into Gt(ROSA)26Sor locus by RMCE. (J:147112, J:243843)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:147112 Taconic, Information obtained from Taconic website. MGI Direct Data Submission. 2006-2017;
All:	2 reference(s)