Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	C5ar1tm1Song
Name:	complement component 5a receptor 1; targeted mutation 1, Wen-Chao Song
MGI ID:	MGI:5426685
Synonyms:	GFP-KI+
Gene:	C5ar1  Location: Chr7:15980668-15993465 bp, - strand  Genetic Position: Chr7, 8.77 cM
Alliance:	C5ar1tm1Song page

Germline Transmission:	Earliest citation of germline transmission: J:184056
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, Hypomorph, Reporter) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 2. A cassette containing (5' to 3') an IRES, EGFP, SV40 polyadenlyation sequence, FRT-flanked neo cassette and loxP site was inserted into the 3' UTR. FACS analysis confirmed reduction of protein expression in elicited peritoneal neutrophils from homozygous mice. (J:184056)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any C5ar1 Mutation:	27 strains or lines available

Original:	J:184056 Dunkelberger J, et al., C5aR expression in a novel GFP reporter gene knockin mouse: implications for the mechanism of action of C5aR signaling in T cell immunity. J Immunol. 2012 Apr 15;188(8):4032-42
All:	1 reference(s)